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The present volume is intended to be a synopsis of seizure disorders with a goal of describing key studies in animals and humans. The translation of pertinent findings from animal studies to human studies, and to potential human studies will be emphasized. Specific cogent animal studies/results which deserve exploration in human seizure disorders will be detailed. The current rate of translation is estimated to be from 7‐9 years, and the “success” rate of translation was very recently listed as less than one half. The success rate is defined as results in human studies which were predicted in advance by animal studies. Both the time between animal and human attempts plus the success rate need improvement.
Epilepsy : Animal & Human CorrelationsDW McCandless PhdSpringer Dordrecht Berlin HeidelbergRe: Joseph Grenier MD PhDThis is a comprehensive text and atlas on animal and human studies of Epilepsy. Animal models of toxin induced and genetically caused syndromes are compared with the mechanisms described in their great detail. Brain wave and EEG correlations of generalized and partial seizures are written and correlated with each other. Stargazer, myoclonic, and tonic clonic epilepsies are dealt with in several chapters. Status epilepticus, Lenox-Gaustoux, & other mechanistic models with their traditional and cutting edge treatments are completedly discussed.I highly recommend this book to the following audiences: students, fellows, researchers, neurologists, neurosurgeons, and undergraduates. Separate chapters describe prognosis, complications, as well as both surgical and drug therapies. Correlations with the underlying biochemical mechanisms are covered in separate chapters.